coronavirus COVID-19

Discussion in 'The BS Topic' started by bourbon_scotch, Feb 29, 2020.

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  1. danbrennan

    danbrennan Veteran Member Lifetime Gold Member

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    Yes, even some of the viruses that cause a cold are corona viruses. COVID-19 is new in humans, though, at least as far as we know.

    https://www.britannica.com/science/coronavirus-virus-group

    "Coronavirus, any virus belonging to the family Coronaviridae. Coronaviruses have enveloped virions (virus particles) that measure approximately 120 nm (1 nm = 10−9 metre) in diameter. Club-shaped glycoprotein spikes in the envelope give the viruses a crownlike, or coronal, appearance. The nucleocapsid, made up of a protein shell known as a capsid and containing the viral nucleic acids, is helical or tubular. The coronavirus genome consists of a single strand of positive-sense RNA (ribonucleic acid)."

    "Coronaviridae is generally considered to contain two genera, Coronavirus and Torovirus, which differ in nucleocapsid morphology, the former being helical and the latter being tubular. Coronaviruses are important agents of gastrointestinal disease in humans, poultry, and bovines."
     
  2. danbrennan

    danbrennan Veteran Member Lifetime Gold Member

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    Yes, I've wondered about the money angle of Hydroxychloroquine. I don't think there is even a patent on it, so the pharmaceutical companies aren't really interested in studying and testing it, since there is really no money in it. Unless they can come up with a more effective variant, or new delivery system.
     
    Last edited: Apr 13, 2020
  3. bourbon_scotch

    bourbon_scotch Veteran Member Lifetime Gold Member

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  4. tom3

    tom3 Veteran Member

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    Hydroxychloroquine: - $0.63 per pill - generic - 11 US manufacturers

    If they can actually prove it works to any extent they will add a mg of sodium and charge $6300 for a regimen dosage.
     
  5. bourbon_scotch

    bourbon_scotch Veteran Member Lifetime Gold Member

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  6. FlaJunkie

    FlaJunkie Veteran Member Lifetime Gold Member

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  7. FlaJunkie

    FlaJunkie Veteran Member Lifetime Gold Member

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    The study:

    Chloroquine diphosphate in two different dosages as adjunctive therapy of hospitalized patients with severe respiratory syndrome in the context of coronavirus (SARS-CoV-2) infection: Preliminary safety results of a randomized, double-blinded, phase IIb clinical trial (CloroCovid-19 Study)

    Abstract
    Summary Background: There is no specific antiviral therapy recommended for the disease caused by SARS-CoV-2 (COVID-19). Recent publications have drawn attention to the possible benefit of chloroquine (CQ). Our study aimed to comprehensively evaluate the safety and efficacy of two different CQ dosages in patients with established severe COVID-19. Methods We performed a parallel, double-blinded, randomized, phase IIb clinical trial, aiming to assess the safety and efficacy of two different CQ dosages as adjunctive therapy of hospitalized patients with SARS in Manaus, Brazilian Amazon. Eligible participants were allocated to receive orally or via nasogastric tube high dose CQ (600mg CQ twice daily for 10 days or total dose 12g); or low dose CQ (450mg for 5 days, twice daily only on the first day, or total dose 2.7g). In addition, all patients received ceftriaxone and azithromycin. This study was registered with ClinicalTrials.gov, number NCT04323527. Findings Out of a pre-defined 440 patients sample size, 81 patients were enrolled. The high dose CQ arm presented more QTc>500ms (25%), and a trend toward higher lethality (17%) than the lower dosage. The fatality rate was 13.5% (95%CI=6.9-23.0%), overlapping with the CI of historical data from similar patients not using CQ (95%CI=14.5-19.2%). In 14 patients with paired samples, respiratory secretion at day 4 was negative in only one patient. Interpretation Preliminary findings suggest that the higher CQ dosage (10-day regimen) should not be recommended for COVID-19 treatment because of its potential safety hazards. Such results forced us to prematurely halt patient recruitment to this arm. Given the enormous global push for the use of CQ for COVID-19, results such as the ones found in this trial can provide robust evidence for updated COVID-19 patient management recommendations.
     
  8. FlaJunkie

    FlaJunkie Veteran Member Lifetime Gold Member

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    Someone is paying news reporters to trash HCL.

    Isn't that interesting?
     
  9. danbrennan

    danbrennan Veteran Member Lifetime Gold Member

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    Not everyone can take hydrochloroquine. When my wife took plaquenil several years ago, she developed blurry vision, so she stopped taking it.
     
  10. bfmgoalie

    bfmgoalie Veteran Member

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    That happens with many medications.
     
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